In 2002, she co-founded A PRIME GROUP (TV and film production) with Dominique Ambiel, and is still a shareholder alongside Raphaël Enthoven and Patrick Poivre d’Arvor.
In 2008, she left the general management of A PRIME to create MASSALA and to be closer to the development of projects and the production of programs. As executive and artistic producer of fiction, she has collaborated with Eric Lavaine, Didier Bourdon, Noémie Merlant, Xavier Dorison, Fabien Nury, Laurent Heynemann, Natacha Régnier, Jean-Pierre Lorit, Didier Decoin, Bruno Solo and Hippolyte Girardot.
Within A PRIME GROUP, she also initiated the program Philosophie on ARTE with Raphaël Enthoven and produced more than fifty episodes of the documentary series Une maison, un artiste on FRANCE TV.
For 6 years she was a deputy member of the Documentary and Cultural Magazines Commission of the CNC.
Living in Bordeaux since 2017, and wishing to participate in the decentralisation of cinema and audiovisual, Charlotte Guénin is also treasurer of the artistic residence, Villa Valmont, located in Lormont.
She is also co-president of the association la Peña, produire en Nouvelle-Aquitaine.