In 2002, she co-founded A PRIME GROUP (TV and film production) with Dominique Ambiel, and is still a shareholder alongside Raphaël Enthoven and Patrick Poivre d’Arvor.
In 2008, she left the general management of A PRIME to create MASSALA and to be closer to the development of projects and the production of programs. As executive and artistic producer of fiction, she has collaborated with Eric Lavaine, Didier Bourdon, Noémie Merlant, Xavier Dorison, Fabien Nury, Laurent Heynemann, Natacha Régnier, Jean-Pierre Lorit, Didier Decoin, Bruno Solo and Hippolyte Girardot.
Within A PRIME GROUP, she also initiated the program Philosophie on ARTE with Raphaël Enthoven and produced more than fifty episodes of the documentary series Une maison, un artiste on FRANCE TV.
Living in Bordeaux since 2017, and wishing to participate in the decentralization of cinema and audiovisual, Charlotte Guénin is also very involved in the creation of a new place of artistic residences, notably cinematographic, the VILLA VALMONT in Lormont (opening in 2022).
Finally, she is an alternate member of the Documentaries and Cultural Magazines Commission of the CNC.